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Prozac Withdrawal Symptoms and Timeline

Medically Verified: 2/1/24

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All of the information on this page has been reviewed and verified by a certified addiction professional.

Prozac (fluoxetine) is a commonly prescribed antidepressant people take to manage symptoms of depression, OCD, panic, and other mental health conditions. Prozac works by increasing serotonin in the brain, and users generally experience elevated mood and fewer depressive symptoms while taking it. But what happens when long-time users need to stop taking Prozac?

Many believe stopping prescription drugs is less complicated than quitting illicit street drugs. However, quitting many prescription drugs, including Prozac, can cause unwanted effects. People who use Prozac may experience uncomfortable withdrawal symptoms if they stop taking it abruptly.

It is essential to understand the effects of Prozac, Prozac withdrawal symptoms, and how to manage symptoms throughout the Prozac withdrawal timeline so that you can stay focused during detox and treatment and make good decisions about your health care.

Reach out to the Charlotte North Carolina Detox specialists to learn more about managing Prozac withdrawal or explore our medically-assisted detox programs.

What is Prozac (Fluoxetine)?

Prozac is the brand name for fluoxetine, a prescription antidepressant people take to manage several mental health conditions, including:

  •  Major depression
  •  Obsessive-compulsive disorder (OCD)
  •  Panic disorders
  •  Eating disorders

Prozac is part of a class of medications known as selective serotonin reuptake inhibitors (SSRIs). It and other SSRIs increase the amount of serotonin available in the brain, which can result in a reduction in depression and overall improved mental health.

Prozac Withdrawal Symptoms

Among all SSRIs, Prozac has the lowest risk for withdrawal symptoms (also known as antidepressant discontinuation syndrome). This medication has a long half-life compared to other SSRIs, meaning it leaves the body more slowly than other drugs. Prozac’s half-life is 4 to 6 days, which allows a gentler withdrawal. Typically, people experience withdrawal symptoms when a drug is about 90% out of the body.

Prozac stands out among other antidepressants because withdrawal symptoms generally don’t appear for several weeks after someone stops taking it. While this may seem like a benefit, Prozac withdrawal can sometimes last for up to 2 months.

This long Prozac withdrawal timeline sometimes means that people are misdiagnosed, and withdrawal symptoms may be mistaken for a relapse. Some people may start taking antidepressants again because of this misunderstanding.

Understanding and recognizing Prozac withdrawal symptoms can help you avoid misdiagnosis. Many people experience Prozac withdrawal symptoms in many different bodily systems.

Here are some of  the most significant and common physical Prozac withdrawal symptoms:

  •  Nausea
  •  Appetite loss
  •  Vomiting
  •  Stomach cramps
  •  Diarrhea
  •  Dizziness
  •  Lightheadedness
  •  Loss of coordination or difficulty walking
  •  Poor balance
  •  Vivid nightmares or unusual dreams
  •  Insomnia
  •  Flu-like muscle pain
  •  Weakness
  •  Fatigue
  •  Headache

Prozac withdrawal can also have emotional and behavioral symptoms, including:

  •  Panic
  •  Suicidal Thoughts
  •  Depression
  •  Mood swings
  •  Angry outbursts
  •  Mania
  •  The sensation of pins and needles
  •  A feeling of electrical shocks or Shivers in the brain
  •  Ringing in the ears
  •  Hypersensitivity to sound
  •  Strange tastes without a source
  •  Tremors
  •  Restless legs
  •  Difficulty controlling chewing and speaking

Stopping Prozac can result in the recurrence of depression symptoms, known as the rebound phenomenon. The severity of Prozac withdrawal symptoms may fluctuate throughout the Prozac withdrawal timeline and can vary from person to person. For some, withdrawal symptoms will be mild and may or may not interfere with some level of functioning. But for others, Prozac withdrawal symptoms will be debilitating and require significant interventions, treatment, and support.

Understanding the Prozac Withdrawal Timeline

People who stopped taking Prozac typically do not have withdrawal symptoms for about a week. About 12 days after the last dose, people may experience the physical, emotional, and behavioral withdrawal symptoms associated with Prozac withdrawal.

Some people may not experience symptoms within the first three to four weeks after quitting Prozac. This typically indicates that the person will not experience Prozac withdrawal symptoms at all.

For those who do experience symptoms, withdrawal generally lasts up to 2 to 3 weeks after symptoms begin and may range from mild to severe.

One of the most significant reasons people continue to take Prozac for long periods is their fear of stopping it. More than half of people who stop taking antidepressants go through withdrawal, and antidepressant withdrawal is associated with a 60% increase in suicidal behaviors.

People who want to stop taking antidepressants, including Prozac, must work with a healthcare provider to slowly taper their dose and take precautions to prevent complications, including suicidal ideation, behaviors, and relapse.

How to Cope With Prozac Withdrawal

Working with a qualified healthcare specialist is critical when stopping antidepressant use. In addition to receiving regular medical care and supervision, there are some things you can do to ease the discomfort of Prozac withdrawal. These include:

  • Attending regular therapy sessions
  • Staying socially active by spending time with friends and family
  • Focusing on getting regular physical activity to improve mental and physical health naturally
  • Taking over-the-counter Herbal Remedies like valerian root and melatonin to improve sleep
  • Using over-the-counter pain relievers and anti-nausea medications to manage withdrawal symptoms

The decision to stop taking Prozac or other antidepressants is a significant one. Work with a doctor to manage your Prozac withdrawal timeline and take extra care of yourself throughout the withdrawal process. If your doctor thinks you should quit taking Prozac, he or she will help you slowly taper off it to avoid severe withdrawal symptoms.

Find Help For Prozac Withdrawal

If you or someone you love needs help managing Prozac withdrawal symptoms, reach out to the team at Charlotte North Carolina Detox now. Our supportive drug and alcohol detox programs can help you regain control over your health and learn how to embrace a healthy, sober lifestyle.


  1. National Alliance on Mental Illness: Fluoxetine (Prozac), Retrieved November 2023 from
  2. National Library of Medicine: Antidepressant discontinuation syndrome, Retrieved November 2023 from
  3. National Library of Medicine: Antidepressant withdrawal and rebound phenomena, Retrieved November 2023 from